BDBM10458 4-AP::4-Aminopyridine 10::CHEMBL284348::DALFAMPRIDINE::pyridin-4-amine

SMILES Nc1ccncc1

InChI Key InChIKey=NUKYPUAOHBNCPY-UHFFFAOYSA-N

Data  4 KI  6 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 10458   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataIC50: 4.37E+6nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataIC50: 5.00E+5nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataIC50: 5.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2006
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataEC50:  2.75E+6nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 3(Human)
Institute of Medical Research Biotechnology Centre

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataKd:  1.95E+5nMAssay Description:Dissociation constant for the blockage of voltage-gated potassium channel subunit Kv1.3 in human lymphocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataIC50: 4.40E+6nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataIC50: 1.90E+6nMAssay Description:Inhibition of Leishmania major PTR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 1(Human)
Dublin Institute of Technology

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataIC50: 8.90E+4nMAssay Description:Inhibition of Kv1.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2019
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataKi: >2.00E+6nMpH: 7.5Assay Description:Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetPlasminogen(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataKi: >2.00E+6nMpH: 7.5Assay Description:Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataKi: >2.00E+6nMpH: 7.5Assay Description:Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataKi:  4.81E+5nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed