BDBM50277158 3123L::CHEBI:17939::CL-13900::GNF-Pf-2016::P-638::Puromycin::TCMDC-123493

SMILES COc1ccc(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)n2cnc3c(ncnc23)N(C)C)cc1

InChI Key InChIKey=RXWNCPJZOCPEPQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277158   

TargetPuromycin-sensitive aminopeptidase(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50277158(CHEBI:17939 | 3123L | CL-13900 | GNF-Pf-2016 | P-6...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-MBP-tagged PSA expressed in Escherichia coli BL21 STAR (DE3) using 4-Ala-MNA as substrate measured fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50277158(CHEBI:17939 | 3123L | CL-13900 | GNF-Pf-2016 | P-6...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged APN (Lys69 to Lys967 residues) using Ala-AMC as substrate measured for 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50277158(CHEBI:17939 | 3123L | CL-13900 | GNF-Pf-2016 | P-6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of porcine aminopeptidase-N using Leu-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPuromycin-sensitive aminopeptidase(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50277158(CHEBI:17939 | 3123L | CL-13900 | GNF-Pf-2016 | P-6...)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of recombinant human puromycin sensitive aminopeptidase using Leu-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50277158(CHEBI:17939 | 3123L | CL-13900 | GNF-Pf-2016 | P-6...)
Affinity DataIC50: 1.80E+7nMAssay Description:Inhibition of human N-terminal His-tagged TDP1 expressed in Escherichia coli BL21 using [32P]-D14Y duplex DNA as substrate incubated for 20 mins by P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed