BDBM50005267 2,5-dimethoxy-4-bromophenethylamine::2-(4-Bromo-2,5-dimethoxy-phenyl)-ethylamine::2-(4-bromo-2,5-dimethoxyphenyl)ethylamine::2c-b::CHEMBL292821::US20240166618, Compound 88

SMILES COc1cc(CCN)c(OC)cc1Br

InChI Key InChIKey=YMHOBZXQZVXHBM-UHFFFAOYSA-N

Data  59 KI  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 50005267   

Target5-hydroxytryptamine receptor 2C(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataEC50:  0.264nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataEC50:  27nMAssay Description:Activity at rat 5HT2A receptor expressed in NIH3T3 cells assessed as stimulation of phospholipase C-mediated IP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Rti International

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataEC50:  7.19E+3nMAssay Description:Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataEC50:  1.93nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataEC50:  0.0311nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataEC50:  1.89nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  0.660nMAssay Description:Displacement of (+/-)-[125I]DOI from human cloned 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  0.880nMAssay Description:Displacement of (+/-)-[125I]DOI from rat cloned 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  1nMAssay Description:Affinity against 5-hydroxytryptamine 2A receptor (D) labeled with [125I]DOI.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  6.31nMAssay Description:5-HT2A Receptor Radioligand Binding. Affinity of the test compounds for the 5-HT2A receptor was determined in radioligand binding experiments with [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  8.25nMAssay Description:5-HT2A Receptor Radioligand Binding. Affinity of the test compounds for the 5-HT2A receptor was determined in radioligand binding experiments with [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2B(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  13.5nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  26.3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  27.6nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  34nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]ketanserin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  34nMAssay Description:Affinity against 5-hydroxytryptamine 2A receptor (K) labeled with [3H]ketanserin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  36nMAssay Description:Affinity against 5-hydroxytryptamine 2C receptor in J1 cells transfected with the rat 5-HT2C gene labeled with [3H]mesulergine.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  36nMAssay Description:Compound was tested for binding affinity towards 5-HT1C (5-HT1C) receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  89.5nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  103nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  104nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  120nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]mesulergine from A9 cells stably expressing rat 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  210nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  241nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  309nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  320nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  665nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  822nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetNischarin(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  2.16E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  3.37E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetCarnitine O-palmitoyltransferase 2, mitochondrial(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  7.12E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetD(1B) dopamine receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetVasopressin V1b receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetVasopressin V1a receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetVasopressin V1a receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetHistamine H4 receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetCannabinoid receptor 2(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Oklahoma

LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
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