BDBM50007403 1-(2-pyrimidyl)piperazine::1-PP::2-Piperazin-1-Yl-Pyrimidine::CHEMBL724::EN300-33983

SMILES C1CN(CCN1)c1ncccn1

InChI Key InChIKey=MRBFGEHILMYPTF-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50007403   

TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50007403(1-PP | CHEMBL724 | 2-Piperazin-1-Yl-Pyrimidine | 1...)
Affinity DataIC50: 2.52E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007403(1-PP | CHEMBL724 | 2-Piperazin-1-Yl-Pyrimidine | 1...)
Affinity DataKi:  1.41E+3nMAssay Description:Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007403(1-PP | CHEMBL724 | 2-Piperazin-1-Yl-Pyrimidine | 1...)
Affinity DataKi:  1.41E+3nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50007403(1-PP | CHEMBL724 | 2-Piperazin-1-Yl-Pyrimidine | 1...)
Affinity DataKi:  4.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007403(1-PP | CHEMBL724 | 2-Piperazin-1-Yl-Pyrimidine | 1...)
Affinity DataKi: >1.00E+4nMAssay Description:The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed