BDBM704237 (Table 4)::US12139488, Example 420

SMILES Cc1c(F)cccc1S(=O)(=O)Nc7ccc(F)c(Nc5ncnc6ccc(n4cnc3c(c2cnccc2N)cccc34)nc56)c7F

InChI Key InChIKey=ZADJCWHBOZCTEA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 704237   

TargetSerine/threonine-protein kinase B-raf(Human)
Université

US Patent
LigandPNGBDBM704237((Table 4) | US12139488, Example 420)
Affinity DataIC50: 1nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Université

US Patent
LigandPNGBDBM704237((Table 4) | US12139488, Example 420)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent