BDBM704226 (Table 4)::US12139488, Example 347

SMILES Cc1c(F)cccc1S(=O)(=O)Nc5ccc(F)c(Nc3ncnc4ccc(n2cnc(CCC#N)c2)nc34)c5F

InChI Key InChIKey=GEBMLAQSGNRDKQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 704226   

TargetSerine/threonine-protein kinase B-raf(Human)
Université

US Patent
LigandPNGBDBM704226((Table 4) | US12139488, Example 347)
Affinity DataIC50: 5.5nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Université

US Patent
LigandPNGBDBM704226((Table 4) | US12139488, Example 347)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent