BDBM50218196 3-beta,28-Dihydroxy-urs-12-ene::CHEMBL399873::US11660306, Example Uveol::Uvaol::urs-12-ene-3beta,28-diol

SMILES C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C

InChI Key InChIKey=XUARCIYIVXVTAE-UHFFFAOYSA-N

Data  2 KI  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50218196   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chosun University

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of human recombinant PTP1B after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Universite Louis Pasteur

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of TDP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-405](Human)
Cold Spring Harbor Laboratory

US Patent
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataKi:  1.00E+3nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 1 [1-321](Human)
Cold Spring Harbor Laboratory

US Patent
LigandPNGBDBM50218196(3-beta,28-Dihydroxy-urs-12-ene | urs-12-ene-3beta,...)
Affinity DataKi:  2.50E+3nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent