BDBM30344 Cipemastat::Trocade

SMILES CN1C(=O)N(C[C@@H]([C@@H](CC2CCCC2)C(=O)N2CCCCC2)C(=O)NO)C(=O)C1(C)C

InChI Key InChIKey=GFUITADOEPNRML-UHFFFAOYSA-N

Data  12 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 30344   

TargetInterstitial collagenase(Human)
Novartis

LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 2.30nMT: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 527nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 58nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 3.40nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 154nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 87nMT: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis

LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  0.530nM ΔG°:  -12.5kcal/mole IC50: 3.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis

LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  3nMAssay Description:Inhibition of matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  3nMAssay Description:Inhibition of matrix metalloprotease-13 (MMP-13).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  4nMAssay Description:Inhibition of matrix metalloprotease-8 (MMP-8).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  56nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  59nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  154nMAssay Description:Inhibition of matrix metalloprotease-2 (MMP-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  230nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  527nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis

LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed