BDBM20510 (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide::AMG 9810::AMG9810::CHEMBL195789::trans-Cinnamide

SMILES CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1

InChI Key InChIKey=GZTFUVZVLYUPRG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 20510   

LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 79nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 350nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 294nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as blockade of acid-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as blockade of capsaicin-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as blockade of acid-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 86nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as blockade of capsaicin-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed