BDBM50397205 AR-C126532XX::AZD-6140::AZD6140::BRILINTA::TICAGRELOR

SMILES CCCSc1nc(c2c(n1)n(nn2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4c5ccc(c(c5)F)F

InChI Key InChIKey=OEKWJQXRCDYSHL-UHFFFAOYSA-N

Data  1 KI  8 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50397205   

TargetP2Y purinoceptor 12(Rat)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 4.16E+3nMAssay Description:Antagonist activity at P2Y12 receptor in Sprague-Dawley rat platelet rich plasma assessed as inhibition of ADP-induced aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Galecto Biotech

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at P2Y12 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Galecto Biotech

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at P2Y12 receptor in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Galecto Biotech

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 320nMAssay Description:Inhibition of P2Y12 in human platelet rich plasma assessed as reduction in ADP-induced platelet aggregation pre-incubated before ADP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Galecto Biotech

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 5.14E+3nMAssay Description:Antagonist activity at P2Y12 in human whole blood assessed as suppression of ADP-induced decrease in PGE1-induced VASP phosphorylation measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Galecto Biotech

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 39nMAssay Description:Inhibition of P2Y12 receptor in human platelet assessed as reduction in ADP-induced VASP phosphorylation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2Y purinoceptor 12(Human)
Galecto Biotech

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 10nMAssay Description:Inhibition of P2Y12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetP2Y purinoceptor 13(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetP2Y purinoceptor 12(Human)
Galecto Biotech

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataKi:  14nMAssay Description:Displacement of [33P]2-MeS-ADP from human recombinant P2Y12 receptor expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed