BDBM50024317 3-{2-[2-Amino-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid::CHEMBL120632::Tetragastrin

SMILES CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

InChI Key InChIKey=RGYLYUZOGHTBRF-UHFFFAOYSA-N

Data  8 KI  2 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50024317   

TargetGastrin/cholecystokinin type B receptor(Rat)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataEC50:  1.40nMAssay Description:Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataIC50: 2.45nMAssay Description:Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataIC50: 2.5nMAssay Description:Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetGastrin/cholecystokinin type B receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKd:  22nMAssay Description:Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]pentagastrin from Cholecystokinin receptor of mouse cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2018
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  10nMAssay Description:Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  19.5nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  93nMAssay Description:Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  93nMAssay Description:Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Guinea pig)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  3.61E+4nMAssay Description:Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Guinea pig)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50024317(Tetragastrin | CHEMBL120632 | 3-{2-[2-Amino-3-(1H-...)
Affinity DataKi:  3.61E+4nMAssay Description:Inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor of Guinea pig pancreatic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed