BDBM50049400 (+/-) taxifolin::(+/-)-Dihydroquercetin::(+/-)-taxifolin::(2R,3R)-2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one::2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one::3,5,7,3',4'-pentahydroxyflavanone::CHEMBL337309::NSC-2801

SMILES OC1C(=O)C(Oc2cc(O)cc(O)c12)c1ccc(O)c(O)c1

InChI Key InChIKey=BYVWXQRJRYELNP-UHFFFAOYSA-N

Data  7 KI  11 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50049400   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 4.37E+4nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease-mediated ammonia production preincubated for 1.5 hrs by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetGlycogen phosphorylase, muscle form(Rabbit)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 4.80E+3nMAssay Description:Binding affinity to rabbit muscular GPa by NMR binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGlycogen phosphorylase, muscle form(Rabbit)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 2.09E+4nMAssay Description:Binding affinity to rabbit muscular GPb by NMR binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of human recombinant MMP12 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 3.39E+4nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 3.46E+4nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKd:  3.74E+4nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CD38 using 20 uM 1, N6-etheno NAD+ as substrate by continuous fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKi:  33nM ΔG°:  -10.2kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKi:  493nM ΔG°:  -8.60kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKi:  9.10E+3nM ΔG°:  -6.87kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKi:  3.39E+4nMAssay Description:Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049400((+/-)-Dihydroquercetin | 3,5,7,3',4'-pentahydroxyf...)
Affinity DataKi:  3.41E+4nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed