BDBM50084661 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-phenylsulfanylmethyl-butyric acid(Bay-12-9566)::CHEMBL261932::Tanomastat

SMILES OC(=O)[C@@H](CSc1ccccc1)CC(=O)c1ccc(cc1)-c1ccc(Cl)cc1

InChI Key InChIKey=JXAGDPXECXQWBC-UHFFFAOYSA-N

Data  10 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50084661   

Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataIC50: 11nMAssay Description:In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataIC50: 301nMAssay Description:In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataIC50: 134nMAssay Description:Inhibition of Matrix metalloprotease-3 (MMP-3) in fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataIC50: 301nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataIC50: 11nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  11nMAssay Description:Inhibition of matrix metalloprotease-2 (MMP-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP-2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  134nMAssay Description:Inhibition of MMP-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  143nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  301nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  301nMAssay Description:Inhibition of MMP-9 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCollagenase 3(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  1.47E+3nMAssay Description:Inhibition of matrix metalloprotease-13 (MMP-13).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  1.47E+3nMAssay Description:Inhibition of MMP-13 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50084661(Tanomastat | 4-(4'-Chloro-biphenyl-4-yl)-4-oxo-2-p...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of MMP-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed