BDBM50344967 2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phenyl-propionic acid::A-4166::AY-4166::CHEMBL783::DJN-608::NATEGLINIDE::SDZ-DJN-608::Starlix

SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)N[C@H](Cc1ccccc1)C(O)=O

InChI Key InChIKey=OELFLUMRDSZNSF-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50344967   

LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetSolute carrier family 15 member 1(Rat)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataIC50: 1.60E+5nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSolute carrier family 15 member 2(Rat)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataIC50: 7.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT2-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of rat Oat1 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50344967(2-[(4-Isopropyl-cyclohexanecarbonyl)-amino]-3-phen...)
Affinity DataKi:  9.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed