BDBM50335583 CHEMBL555196::silvestrol

SMILES COc1ccc(cc1)[C@]23[C@@H]([C@H]([C@H]([C@]2(c4c(cc(cc4OC)O[C@H]5[C@@H](OC[C@@H](O5)[C@@H](CO)O)OC)O3)O)O)C(=O)OC)c6ccccc6

InChI Key InChIKey=GVKXFVCXBFGBCD-UHFFFAOYSA-N

Data  1 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50335583   

TargetTranscription factor p65(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50335583(silvestrol | CHEMBL555196)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NF-kappaB p65 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by ch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335583(silvestrol | CHEMBL555196)
Affinity DataEC50:  0.800nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335583(silvestrol | CHEMBL555196)
Affinity DataEC50:  7nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)