BDBM50341711 CHEMBL479488::schisandrin B

SMILES COc1cc2CC(C)C(C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC

InChI Key InChIKey=RTZKSTLPRTWFEV-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50341711   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 1.00E+9nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 1.74E+6nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of flag-tagged ATR expressed in HEK293T cells using PHAS-1 as substrate after 20 mins by autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 1.25nMAssay Description:TP_TRANSPORTER: inhibition of VCR transport in HL60/ADR cells (overexpression of MRP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 4.18E+3nMAssay Description:TP_TRANSPORTER: inhibition of VP-16 transport in HL60/ADR cells (overexpression of MRP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 9.49nMAssay Description:TP_TRANSPORTER: inhibition of VCR transport in HL60/MRP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 139nMAssay Description:TP_TRANSPORTER: inhibition of DNR transport in HL60/ADR cells (overexpression of MRP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 204nMAssay Description:TP_TRANSPORTER: inhibition of DNR transport in HL60/MRP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50341711(schisandrin B | CHEMBL479488)
Affinity DataIC50: 2.24E+3nMAssay Description:TP_TRANSPORTER: inhibition of VP-16 transport in HL60/MRP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed