BDBM50414251 SALVIANOLIC ACID B

SMILES OC(OC(Cc1ccc(O)c(O)c1)C(O)=O)C1C(Oc2cc(O)cc(\C=C\C(=O)OC(Cc3ccc(O)c(O)c3)C(O)=O)c12)c1ccc(O)c(O)c1

InChI Key InChIKey=YLSNESYAOIRZEA-UHFFFAOYSA-N

Data  5 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50414251   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Max Planck Institute of Biochemistry

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of c-SRC SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Max Planck Institute of Biochemistry

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of LCK SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of amyloid beta (1 to 40) aggregation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataIC50: 5.00E+3nMAssay Description:Destabilization of preformed amyloid beta (1 to 40) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataKi:  36nM ΔG°:  -10.1kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataKi:  66nM ΔG°:  -9.79kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataKi:  454nM ΔG°:  -8.65kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50414251(SALVIANOLIC ACID B)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed