BDBM50271827 2-Isopropyl-isothiourea::CHEMBL483091::S-ISOPROPYL-ISOTHIOUREA

SMILES CC(C)SC(=N)N

InChI Key InChIKey=XSSNABKEYXKKMK-UHFFFAOYSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50271827   

TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271827(S-ISOPROPYL-ISOTHIOUREA | 2-Isopropyl-isothiourea ...)
Affinity DataKi:  9nMAssay Description:Inhibition of iNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271827(S-ISOPROPYL-ISOTHIOUREA | 2-Isopropyl-isothiourea ...)
Affinity DataKi:  22nMAssay Description:Inhibition of eNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50271827(S-ISOPROPYL-ISOTHIOUREA | 2-Isopropyl-isothiourea ...)
Affinity DataKi:  37nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50271827(S-ISOPROPYL-ISOTHIOUREA | 2-Isopropyl-isothiourea ...)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of nNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed