BDBM50038370 2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-1-methyl-ethylamine::CHEMBL6620::Racemic DOTFM::US20240166618, Compound 2C-TFM

SMILES COc1cc(c(OC)cc1CC(C)N)C(F)(F)F

InChI Key InChIKey=WPGOTSORDNBMHP-UHFFFAOYSA-N

Data  5 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50038370   

Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50038370(Racemic DOTFM | 2-(2,5-Dimethoxy-4-trifluoromethyl...)
Affinity DataEC50:  68.4nMAssay Description:Ability to stimulate phosphoinositide hydrolysis in NIH3T3 cells expressing the 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Universidad De Chile

Curated by ChEMBL
LigandPNGBDBM50038370(Racemic DOTFM | 2-(2,5-Dimethoxy-4-trifluoromethyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspensionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50038370(Racemic DOTFM | 2-(2,5-Dimethoxy-4-trifluoromethyl...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity at cloned rat 5-hydroxytryptamine 2A receptor using [3H]DOB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50038370(Racemic DOTFM | 2-(2,5-Dimethoxy-4-trifluoromethyl...)
Affinity DataKi:  3.78nMAssay Description:Binding affinity at cloned rat 5-hydroxytryptamine 2C receptor using [3H]DOI as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Gilgamesh Pharmaceuticals

US Patent
LigandPNGBDBM50038370(Racemic DOTFM | 2-(2,5-Dimethoxy-4-trifluoromethyl...)
Affinity DataKi:  15.8nMAssay Description:5-HT2A Receptor Radioligand Binding. Affinity of the test compounds for the 5-HT2A receptor was determined in radioligand binding experiments with [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50038370(Racemic DOTFM | 2-(2,5-Dimethoxy-4-trifluoromethyl...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50038370(Racemic DOTFM | 2-(2,5-Dimethoxy-4-trifluoromethyl...)
Affinity DataKi:  2.23E+3nMAssay Description:Tested for the binding affinity against the site labelled by the 5-hydroxytryptamine 1A receptor agonist [3H]- 8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed