BDBM50095495 CHEMBL262697::Pyrrolidine-1-carbonitrile

SMILES N#CN1CCCC1

InChI Key InChIKey=QJRYYOWARFCJQZ-UHFFFAOYSA-N

Data  1 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50095495   

TargetDipeptidyl peptidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human recombinant cathepsin C after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human recombinant cathepsin K after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetProcathepsin L(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human recombinant cathepsin L after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human recombinant cathepsin S after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human recombinant cathepsin B after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 3.40E+3nMpH: 7.0Assay Description:Effect of 10 mM of GSH on the inhibitory activity against Cathepsin K, at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 1.50E+3nMpH: 5.5Assay Description:Effect of 10 mM of GSH on the inhibitory activity of compound against Cathepsin K, at pH 5.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity tested against Human Cathepsin B using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 1.63E+3nMpH: 5.5Assay Description:Inhibition of Cathepsin K at pH 5.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 2.30E+3nMpH: 7.0Assay Description:Inhibition of Cathepsin K at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin L using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin K using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(Pyrrolidine-1-carbonitrile | CHEMBL262697)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition constant against human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed