BDBM50324671 CHEMBL1221984::Purmorphamine

SMILES C1CCC(CC1)n1cnc2c(Nc3ccc(cc3)N3CCOCC3)nc(Oc3cccc4ccccc34)nc12

InChI Key InChIKey=FYBHCRQFSFYWPY-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50324671   

TargetSmoothened homolog(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50324671(Purmorphamine | CHEMBL1221984)
Affinity DataEC50:  800nMAssay Description:Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50324671(Purmorphamine | CHEMBL1221984)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50324671(Purmorphamine | CHEMBL1221984)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50324671(Purmorphamine | CHEMBL1221984)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at SMO receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed