BDBM22915 3-(1H-imidazol-4-yl)propylphenylmethyl ether::5-[3-(benzyloxy)propyl]-1H-imidazole::CHEMBL61618::Proxyfan

SMILES c1ccc(cc1)COCCCc2cnc[nH]2

InChI Key InChIKey=WNWALBVQAAIULR-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 22915   

TargetHistamine H3 receptor(Human)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM22915(CHEMBL61618 | 5-[3-(benzyloxy)propyl]-1H-imidazole...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of [125I]iodoproxyfan binding to human histamine H3 receptor of CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM22915(CHEMBL61618 | 5-[3-(benzyloxy)propyl]-1H-imidazole...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to rat Histamine H3 receptor in CHO-K1 cells using [125I]iodoproxyfan as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Human)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM22915(CHEMBL61618 | 5-[3-(benzyloxy)propyl]-1H-imidazole...)
Affinity DataKi:  13nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH3R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM22915(CHEMBL61618 | 5-[3-(benzyloxy)propyl]-1H-imidazole...)
Affinity DataKi:  20nMAssay Description:In vitro antagonistic activity against histamine H3-receptor in an assay with K+-evoked depolarisation-induced release of [3H]histamine of synaptosom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PDB3D3D Structure (crystal)
TargetHistamine H4 receptor(Human)
Vrije Universiteit Amsterdam

LigandPNGBDBM22915(CHEMBL61618 | 5-[3-(benzyloxy)propyl]-1H-imidazole...)
Affinity DataKi:  50nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed