BDBM50010617 (-)-3-(1-Propyl-piperidin-3-yl)-phenol::(S)-3-(1-propylpiperidin-3-yl)phenol::3-((S)-1-Propyl-piperidin-3-yl)-phenol::3-(1-Propyl-piperidin-3-yl)-phenol::3PPP,(+)::CHEMBL7549::Preclamol

SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1

InChI Key InChIKey=HTSNFXAICLXZMA-UHFFFAOYSA-N

Data  29 KI  7 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50010617   

TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  163nMAssay Description:Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataIC50: 700nMAssay Description:Ability to displace [3H]spiroperidol, from dopamine receptor D2 specific binding sites of rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataIC50: 55nMAssay Description:In vitro inhibition of [3H]N-0437 binding to Dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataIC50: 165nMAssay Description:In vitro for binding affinity against sigma receptor using [3H](+)-3-PPP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataIC50: 420nMAssay Description:Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  9.80nMAssay Description:Effective concentration required for agonistic activity against human D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  19nMAssay Description:Effective concentration required for agonistic activity against rat D2 long receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataIC50: 810nMAssay Description:Displacement of (+)-3PPP from sigma receptor of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2014
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataIC50: 417nMAssay Description:Displacement of spiperone from dopamine receptor D2 of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2014
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  60nMAssay Description:Effective concentration required for agonistic activity against human D4.2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  19nMAssay Description:Effective concentration required for agonistic activity against rat D2 short receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataIC50: 3.40E+3nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  844nMAssay Description:Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataEC50:  376nMAssay Description:Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  8.5nMAssay Description:In vitro binding affinity against cloned mammalian dopamine D2 autoreceptor, expressed in CHO-K1 cells, using [3H]U-86170 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  9nMAssay Description:Binding affinity of compound measured using [3H]spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 9.0/1800)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  16nMAssay Description:Binding affinity of compound measured using [3H]spiperone for the cloned human dopamine receptor D4.4 (high/low affinity is given as 16/1300)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  17.4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  21nMAssay Description:In vitro binding affinity to rat striatal Dopamine receptor D2 was determined using the agonist [3H]quinpirole to label the high affinity state (D2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  25nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 25/1600)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  27nMAssay Description:Binding affinity of compound measured using [3H]spiperone for the cloned human dopamine receptor D2 short (high/low affinity is given as 27/1800)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  39nMAssay Description:Affinity against recombinant dopamine receptor (DA) D2 expressed in CHO-K1 cells, using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
The Johns Hopkins University

Curated by PDSP Ki Database
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  45nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
The Johns Hopkins University

Curated by PDSP Ki Database
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  49nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Bovine)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  52nMAssay Description:Binding affinity of compound against Dopamine receptor D2 was measured using [3H]pramipexole in Bovine striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  76nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  86nMAssay Description:In vitro affinity against dopamine receptor D2 using [3H]DP-5,6-ADTN radioligand in rat striatal homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  100nMAssay Description:Affinity against striatal dopamine D2 receptors using [3H]spiperone as radioligand in rats.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  132nMAssay Description:Tested for in vitro binding affinity against cloned mammalian dopamine D3 receptor, expressed in CHO-K1 cells, using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  132nMAssay Description:Binding affinity to human dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  137nMAssay Description:Binding affinity to human dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  234nMAssay Description:Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  530nMAssay Description:Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, high affinity siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  702nMAssay Description:In vitro binding affinity to rat striatal Dopamine receptor D2 was determined using the antagonist [3H]spiperone + GTP to label the low affinity stat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  2.10E+3nMAssay Description:Tested for binding affinity against Dopamine receptor D2 like from bovine striatum membranes by using [3H]YM-09151-2 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  2.27E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  3.27E+3nMAssay Description:Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  8.00E+3nMAssay Description:Tested for affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT in homogenized rat brain tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
The Johns Hopkins University

Curated by PDSP Ki Database
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
The Johns Hopkins University

Curated by PDSP Ki Database
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Bovine)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50010617(Preclamol | (-)-3-(1-Propyl-piperidin-3-yl)-phenol...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, low affinity siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed