BDBM85245 CAS_36322-90-4::NSC_4856::Piroxicam

SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O

InChI Key InChIKey=QYSPLQLAKJAUJT-UHFFFAOYSA-N

Data  12 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 85245   

TargetSolute carrier family 22 member 6(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 2.05E+4nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 2 mins followed by substrate addition in presence of TMPD b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2018
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 2.54E+5nMAssay Description:Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate preincubated for 2 mins followed by substrate addition in presence of TMPD b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2018
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 2.55E+5nMAssay Description:Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate preincubated for 2 mins followed by substrate addition in presence of TMPD b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2018
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.02E+5nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 2 mins followed by substrate addition in presence of TMPD b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2018
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase in rat neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2018
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Bovine)
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of bovine Prostaglandin G/H synthase after oral administrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 2.10E+4nMAssay Description:Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 2.18E+5nMAssay Description:Tested for inhibitory activity against Prostaglandin G/H synthase 2 from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 5-lipoxygenase from rat peritoneal neutrophils after oral administrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataIC50: 1.30E+3nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  2.11E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  2.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  2.68E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  4.88E+3nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  7.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  9.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  1.98E+4nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  5.20E+4nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  1.20E+6nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 11(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  1.08E+5nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT4-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed