BDBM50005886 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone::1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione::CHEMBL42624::Physcione::physcion

SMILES COc1cc(O)c2C(=O)c3c(O)cc(C)cc3C(=O)c2c1

InChI Key InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50005886   

TargetGenome polyprotein(Human rhinovirus B)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibitory activity against HRV 3Cpro using HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataIC50: 2.81E+6nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of rat liver cytosolic TrxR1 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetThioredoxin reductase 2, mitochondrial(Rat)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of rat liver mitochondrial TrxR2 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataIC50: 6.20E+3nMAssay Description:Compound was tested for the enzyme inhibitory activity against Human Leukocyte Elastase (HLE) at 65 uM concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of bovine kidney alpha-fucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50005886(physcion | 1,8-Dihydroxy-3-methoxy-6-methylanthraq...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]PSB0413 from human platelet P2Y12 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed