BDBM14675 CHEMBL26128::Fragment 5::Phenylphosphate::phenoxyphosphonic acid

SMILES c1ccc(cc1)OP(=O)(O)O

InChI Key InChIKey=CMPQUABWPXYYSH-UHFFFAOYSA-N

Data  5 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14675   

LigandPNGBDBM14675(CHEMBL26128 | phenoxyphosphonic acid | Fragment 5 ...)
Affinity DataIC50: 3.50E+6nMpH: 7.4 T: 2°CAssay Description:SPA uses 125I as energy donor and scintillant-coated beads as energy acceptor. The labeled ligand is captured by the biotinylated Src-SH2 protein imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14675(CHEMBL26128 | phenoxyphosphonic acid | Fragment 5 ...)
Affinity DataIC50: 5.00E+6nMAssay Description:Binding affinity for Src protein tyrosine kinase SH2 domain using surface plasmon resonance (SPR) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | phenoxyphosphonic acid | Fragment 5 ...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity against Lck SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14675(CHEMBL26128 | phenoxyphosphonic acid | Fragment 5 ...)
Affinity DataIC50: 3.00E+5nMAssay Description:Binding affinity for Src protein tyrosine kinase SH2 domain using scintillation proximity binding assay (SPA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14675(CHEMBL26128 | phenoxyphosphonic acid | Fragment 5 ...)
Affinity DataIC50: 2.50E+6nMAssay Description:The compound was evaluated for its binding affinity towards phosphotyrosine binding pocket of Src protein tyrosine kinase SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
The University of Birmingham

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | phenoxyphosphonic acid | Fragment 5 ...)
Affinity DataIC50: 3.25E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed