BDBM50012855 10H-Phenothiazin::10H-phenothiazine::CHEMBL828::cid_7108::dibenzo-1,4-thiazine::phenothiazine

SMILES N1c2ccccc2Sc2ccccc12

InChI Key InChIKey=WJFKNYWRSNBZNX-UHFFFAOYSA-N

Data  5 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50012855   

TargetNADPH oxidase 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataIC50: 349nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetNADPH oxidase 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataIC50: 369nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of 5-lipoxygenase pathway in rat basophilic leukemia (RBL-1) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataIC50: 940nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase pathway in rat basophilic leukemia (RBL-1) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataIC50: 2.60E+4nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPleiotropic ABC efflux transporter of multiple drugs(Baker's yeast)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataKi: >500nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataKi:  1.47E+3nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(1A) dopamine receptor(Rat)
UniversitÉ

Curated by PDSP Ki Database
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
UniversitÉ

Curated by PDSP Ki Database
LigandPNGBDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed