BDBM50106477 CHEMBL265801::FGGFTGARKSARKLADE::Phe-GGFTGARKSARKLAD-Glu

SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O

InChI Key InChIKey=PUPSFQBPHILNGY-UHFFFAOYSA-N

Data  1 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50106477   

TargetNociceptin receptor(Human)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106477(FGGFTGARKSARKLADE | Phe-GGFTGARKSARKLAD-Glu | CHEM...)
Affinity DataIC50: 0.286nMAssay Description:Displacement of [3H]NC from human ORL1 receptor expressing HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106477(FGGFTGARKSARKLADE | Phe-GGFTGARKSARKLAD-Glu | CHEM...)
Affinity DataEC50:  1.93nMAssay Description:Binding of compound to cell membranes expressing human ORL1 receptor in HEk-293 cells using [32S]GTP-gamma-SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106477(FGGFTGARKSARKLADE | Phe-GGFTGARKSARKLAD-Glu | CHEM...)
Affinity DataEC50:  0.219nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106477(FGGFTGARKSARKLADE | Phe-GGFTGARKSARKLAD-Glu | CHEM...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]NC-NH2 binding to mouse forebrain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed