BDBM50055935 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione::5-ethyl-5-(1-methylbutyl)barbituric acid::5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione::5-ethyl-5-(sec-pentyl)barbituric acid::CHEMBL448::Nembutal::PENTOBARBITAL::Pentobarbitone

SMILES CCC[C@H](C)C1(C(=O)NC(=O)NC1=O)CC

InChI Key InChIKey=WEXRUCMBJFQVBZ-UHFFFAOYSA-N

Data  1 KI  5 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50055935   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataIC50: 2.28E+7nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataEC50:  5.00E+4nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Displacement of [3H]R-(-)-14 from human FLAG-tagged alpha1 GABA A receptor expressed in HEK293S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataIC50: 8.80E+4nMAssay Description:Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataIC50: 2.99E+5nMAssay Description:Inhibition of Cav1.2 current measured using PatchXpress automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subuni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed