BDBM50263192 CHEMBL478858::CHEMBL564483::Pactimibe::[7-(2,2-Dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid

SMILES CCCCCCCCN1CCc2c1c(NC(=O)C(C)(C)C)c(C)c(CC(O)=O)c2C

InChI Key InChIKey=TXIIZHHIOHVWJD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263192   

TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | [7-(2,2-Dimethylprop...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | [7-(2,2-Dimethylprop...)
Affinity DataIC50: 300nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL after differentiation assessed as effect on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | [7-(2,2-Dimethylprop...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of ACAT in Japanese White rabbit liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 2(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | [7-(2,2-Dimethylprop...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of macrophage ACAT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | [7-(2,2-Dimethylprop...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed