BDBM76863 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one::3-[3-(4-benzhydrylpiperazino)propyl]-1H-benzimidazol-2-one::3-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1H-benzimidazol-2-one::3-[3-[4-(diphenylmethyl)piperazin-1-yl]propyl]-1H-benzimidazol-2-one::MLS000028549::OXATOMIDE::SMR000058301::cid_4615

SMILES O=c1[nH]c2ccccc2n1CCCN1CCN(CC1)C(c1ccccc1)c1ccccc1

InChI Key InChIKey=BAINIUMDFURPJM-UHFFFAOYSA-N

Data  1 KI  2 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 76863   

TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataEC50:  5.15E+3nMAssay Description:Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetHistamine H1 receptor(Guinea pig)
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataEC50:  400nMAssay Description:Activation of PXR in human cryopreserved hepatocytes assessed as induction of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Rat)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataEC50:  2.51E+4nMAssay Description:Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataEC50:  7.90E+3nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataEC50:  7.10E+3nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataEC50:  3.50E+3nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Takasaki University of Health and Welfare

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataIC50: 830nMAssay Description:Antagonist activity at P2X7 receptor in human RPMI-8226 cells assessed as inhibition of ATP-induced Ca2+ influx by fura-2 staining based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM76863(MLS000028549 | OXATOMIDE | 3-[3-[4-(diphenylmethyl...)
Affinity DataKi:  62.7nMAssay Description:Ability to compete with [3H]YM-09151-2 binding to the human dopamine receptor D3 transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed