BDBM50255753 CHEMBL481611::MK-0822::Odanacatib

SMILES CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N

InChI Key InChIKey=FWIVDMJALNEADT-UHFFFAOYSA-N

Data  3 KI  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50255753   

TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of cathepsin L in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Cathepsin B (unknown origin) assessed as inhibition of AFC release using sequence RR labelled with AFC as substrate by fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCathepsin S(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 500nMAssay Description:Inhibition of Cathepsin S (unknown origin) assessed as inhibition of AFC release using sequence VVR labelled with AFC as substrate by fluorescence ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Cathepsin K (unknown origin) assessed as inhibition of AFC release using sequence LR labelled with AFC as substrate by fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 45nMAssay Description:Inhibition of cathepsin S in human ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 762nMAssay Description:Inhibition of cathepsin VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of cathepsin B in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin F(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 795nMAssay Description:Inhibition of cathepsin FMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 1nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 60nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 183nMAssay Description:Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataKi:  126nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of Cathepsin L (unknown origin) using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed