BDBM50303240 (1S,3'R,4'S,5'S,6'R)-5-chloro-6-(4-ethoxybenzyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4',5'-triol::CHEMBL565784::O-spiroketal glucoside

SMILES CCOc1ccc(Cc2cc3c(CO[C@]33O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc2Cl)cc1

InChI Key InChIKey=WUEOKKVPVLUFPP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303240   

TargetSodium/glucose cotransporter 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50303240(O-spiroketal glucoside | (1S,3'R,4'S,5'S,6'R)-5-ch...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human SGLT1 transfected in COS-7 cells assessed as AMG uptake after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50303240(O-spiroketal glucoside | (1S,3'R,4'S,5'S,6'R)-5-ch...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human SGLT2 transfected in HEK293.ETN cells assessed as AMG uptake after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50303240(O-spiroketal glucoside | (1S,3'R,4'S,5'S,6'R)-5-ch...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 1.5 hrs by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50303240(O-spiroketal glucoside | (1S,3'R,4'S,5'S,6'R)-5-ch...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human SGLT1 expressed in african green monkey COS7 cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed