BDBM82551 C18130::CAS_105618-26-6::NOR-BNI (HCI)2::NORBNI
SMILES c1cc(c2c3c1C[C@@H]4[C@]5([C@]3(CCN4CC6CC6)[C@@H](O2)c7c(c8c([nH]7)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)Cc1c2c(c(cc1)O)O9)CC1CC1)C5)O)O
InChI Key InChIKey=APSUXPSYBJVPPS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 144 hits for monomerid = 82551
Affinity DataIC50: 181nMAssay Description:Inhibitory activity against kappa-opioid receptor in guinea pig ileum longitudinal muscle using ethylketazocineMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibitory activity against mu-opioid receptor in guinea pig ileum longitudinal muscle using morphineMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of Opioid receptor delta 1 by displacing 1 nM [3H]DPDPE in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human delta opioid receptor expressed in HEK cells assessed as inhibition of SNC-80-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human delta opioid receptor assessed as inhibition of SNC80-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0390nMAssay Description:Stimulation of U-69,593 binding at human recombinant Opioid receptor kappa 1 transfected into CHO cells.More data for this Ligand-Target Pair
Affinity DataEC50: 4.40nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding at human recombinant Opioid receptor delta 1 transfected into CHO cells.More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Stimulation of DAMGO binding in recombinant human Opioid receptor mu 1 transfected into CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 380nMAssay Description:Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
Affinity DataIC50: 212nMAssay Description:Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 212nMAssay Description:Antagonist activity at human mu opioid receptor expressed in HEK cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against delta-opioid receptor in mouse vas deferens preparation using DADLEMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
Affinity DataKd: 1.65nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in mouse brain tissueMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Antagonist activity at human KOR expressed in CHO cell membranes assessed as inhibition of U50488-induced [35S]-GTPgammaS binding preincubated for 5 ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS bindin...More data for this Ligand-Target Pair
Affinity DataKi: 0.0270nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0380nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding from Opioid receptor kappa 1 in Guinea pig Caudate stimulated by U69,593More data for this Ligand-Target Pair
Affinity DataKi: 0.0380nMAssay Description:Inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (U69593, kappa-receptor), in guinea pig caudate membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.0390nMAssay Description:Compound was evaluated for its binding affinity by displacing [3H]U-69593 to human cloned Kappa opioid receptor transfected into CHO cells using [35S...More data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM U69,593 as the agonist ligand for kappa-re...More data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Effect on binding affinity of mutational exchange of Glu297 in the Opioid receptor kappa 1 in transiently expressed rat cos-7 cells activity expresse...More data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against wild-type Opioid receptor kappa 1 in COS-7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.153nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Displacement of [125I]-IBNalA from KOR-1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]U-69593 from human recombinant Opioid receptor kappa 1 on CHO cell membranes.More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Ability to displace [3H]U-69593 from human recombinant Opioid receptor kappa 1 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Binding affinity against cloned human Opioid receptor kappa 1 transfected into chinese hamster ovary cells using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of [3H]U-69593 binding to human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Compound was evaluated for its binding affinity to CHO cells expressing cloned human Opioid receptor kappa 1 by displacing [3H]U-69593More data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Displacement of [125I]-IBNtxA from KOR-1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]diprenorphine from delta-W284E-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Binding affinity of compound was measured against Opioid receptor kappa 1 on electrically stimulated guinea pig ileal longitudinal muscle myenteric p...More data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:The binding affinity on kappa-opioid receptor using [3H]- U-69,593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:Binding affinity determined on Opioid receptor kappa 1 in Guinea pig brain membranes using radioligand [3H]U-69593More data for this Ligand-Target Pair