BDBM50220832 CHEMBL8211::N-ethylmaleimide

SMILES CCN1C(=O)C=CC1=O

InChI Key InChIKey=HDFGOPSGAURCEO-UHFFFAOYSA-N

Data  1 KI  4 IC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50220832   

TargetGenome polyprotein(Hepacivirus C)
University of Wisconsin-Milwaukee

LigandPNGBDBM50220832(CHEMBL8211 | N-ethylmaleimide)
Affinity DataIC50: 5.30E+5nMpH: 7.5 T: 2°CAssay Description:Binding assays containing 25 mM MOPS pH 7.5, 1.25 mM MgCl2, 20 nM Cy5-dT15, and 200 nM NS3h_1b were incubated 5 min at RT. Following addition of indi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50220832(CHEMBL8211 | N-ethylmaleimide)
Affinity DataIC50: 1.66E+4nMAssay Description:Displacement of [3H]2-OG from human MGL by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50220832(CHEMBL8211 | N-ethylmaleimide)
Affinity DataIC50: 4.68E+4nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50220832(CHEMBL8211 | N-ethylmaleimide)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of rat cerebellar membranes MAGL-like activity preincubated for 30 mins followed by 2-AG substrate addition after 90 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target14 kDa phosphohistidine phosphatase(Human)
Ulsan National Institute of Science and Technology (UNIST)

Curated by ChEMBL
LigandPNGBDBM50220832(CHEMBL8211 | N-ethylmaleimide)
Affinity DataKi:  2.09E+5nMAssay Description:Inhibition of human PHPT1 expressed in Escherichia coli BL21 (DE3) using pNPP as substrate assessed as inhibition constant by reciprocal analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed