BDBM7944 1-(1H-imidazol-1-yl)ethan-1-one::Imidazole N-1 deriv. 5::N-Acetylimidazole::US9138393, 1- Acetylimidazole::US9144538, 1-Acetylimidazole

SMILES CC(=O)n1ccnc1

InChI Key InChIKey=VIHYIVKEECZGOU-UHFFFAOYSA-N

Data  1 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7944   

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM7944(N-Acetylimidazole | 1-(1H-imidazol-1-yl)ethan-1-on...)
Affinity DataIC50: 1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM7944(N-Acetylimidazole | 1-(1H-imidazol-1-yl)ethan-1-on...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

LigandPNGBDBM7944(N-Acetylimidazole | 1-(1H-imidazol-1-yl)ethan-1-on...)
Affinity DataKi:  1.07E+5nM ΔG°:  -5.50kcal/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2006
Entry Details Article
PubMed