BDBM50343928 CHEMBL1780216::Muraymycin D2

SMILES CC(C)C[C@@H](C(=O)NCCCN[C@@H]([C@@H]([C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)O)O)O[C@H]3[C@@H]([C@@H]([C@H](O3)CN)O)O)C(=O)O)NC(=O)[C@H]([C@@H]4CCN=C(N4)N)NC(=O)N[C@@H](C(C)C)C(=O)O

InChI Key InChIKey=RRTIONDZEJYWBN-UHFFFAOYSA-N

Data  2 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50343928   

TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Bacillus subtilis (strain 168))
TBA

Curated by ChEMBL
LigandPNGBDBM50343928(Muraymycin D2 | CHEMBL1780216)
Affinity DataIC50: 10nMAssay Description:Inhibition of purified Bacillus subtilis MraY assessed as incorporation of MurNAc-[14C]pentapeptide into lipid 1 after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Bacillus subtilis (strain 168))
TBA

Curated by ChEMBL
LigandPNGBDBM50343928(Muraymycin D2 | CHEMBL1780216)
Affinity DataIC50: 10nMAssay Description:Inhibition of Bacillus subtilis MraY using radiolabeled UDP-MurNAc-[14C]pentapeptide as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase(Thermotoga maritima (strain ATCC 43589 / MSB8 / DS...)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50343928(Muraymycin D2 | CHEMBL1780216)
Affinity DataIC50: 1.23E+6nMAssay Description:Inhibition of Thermotoga maritima WecA using radiolabeled UDP-[14C]GlcNAc as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Bacillus subtilis (strain 168))
TBA

Curated by ChEMBL
LigandPNGBDBM50343928(Muraymycin D2 | CHEMBL1780216)
Affinity DataKi:  7.60nMAssay Description:Competitive inhibition of Bacillus subtilis MraY using UDP-MurNAc-pentapeptide as substrate after 30 mins by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Bacillus subtilis (strain 168))
TBA

Curated by ChEMBL
LigandPNGBDBM50343928(Muraymycin D2 | CHEMBL1780216)
Affinity DataKi:  7.60nMAssay Description:Noncompetitive inhibition of Bacillus subtilis MraY using radiolabeled UDP-GlcNAc as substrate after 30 mins by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed