BDBM25899 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide::Diulo::Metolazone::Microx::Zaroxolyn

SMILES CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O

InChI Key InChIKey=AQCHWTWZEMGIFD-UHFFFAOYSA-N

Data  15 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 25899   

TargetCarbonic anhydrase 3(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKd: >2.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKd:  2.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 7(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  2.10nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  5.40nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Mouse)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  15nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  216nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  312nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  320nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  750nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 6(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  1.71E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  2.00E+3nM ΔG°:  -7.77kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 14(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  5.43E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  5.40E+4nM ΔG°:  -5.82kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetCarbonic anhydrase 3(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi:  6.10E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 3(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM25899(7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4...)
Affinity DataKi: >2.00E+5nM ΔG°: >-5.04kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed