BDBM50216297 6',7',10,11-tetramethoxyemetan::CHEMBL50588::Emetin::Emetine::cephaeline methyl ether::methyl cephaeline

SMILES CC[C@H]1CN2CCc3cc(c(cc3[C@@H]2C[C@@H]1C[C@@H]4c5cc(c(cc5CCN4)OC)OC)OC)OC

InChI Key InChIKey=AUVVAXYIELKVAI-UHFFFAOYSA-N

Data  18 IC50  2 EC50

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50216297   

LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetGenome polyprotein(ZIKV)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataEC50:  8.70nMAssay Description:Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC59 infected in African green monkey Vero cells infected with supernatants from virus-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGenome polyprotein(ZIKV)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataEC50:  53nMAssay Description:Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in HEK293 cells assessed as antiviral activity by measuring NS1 protein expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of LFA1:CD11a/CD18/ICAM1-mediated human HL60 cell adhesion to human HeLa cells expressing ICAM1 by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 110nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 83nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human HeLa cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.07E+6nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetSerine hydrolase RBBP9(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 7.80E+3nMAssay Description:Displacement of fluorophosphate-rhodamine from RBBP9 transfected in human HEK293T cells proteomes after 30 mins by SDS-PAGE gel fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.30E+5nMAssay Description:TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 1.16E+5nMAssay Description:TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 2.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 2.07E+5nMAssay Description:TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 9.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 9.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50216297(6',7',10,11-tetramethoxyemetan | Emetin | Emetine ...)
Affinity DataIC50: 3.51E+4nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed