BDBM50148348 (R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-propyl ester::1-oleoyl lysophosphatidic acid::CHEMBL117021::lysophosphatidic acid

SMILES CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)O)O

InChI Key InChIKey=WRGQSWVCFNIUNZ-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 Kd  18 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50148348   

TargetLysophosphatidic acid receptor 5(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at LPA5 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataKd:  5.60nMAssay Description:Binding affinity to LPA1 receptor (unknown origin) by cell-based backscattering interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  830nMAssay Description:Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
Technical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 2(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 3(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  77nMAssay Description:Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 4(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 5(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  55nMAssay Description:Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 6(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  970nMAssay Description:Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAutotaxin(Human)
Technical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataIC50: 442nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 3(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at LPA3 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at LPA1 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 2(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 5(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  510nMAssay Description:Agonist activity at FLAG-tagged human LPA5 expressed in rat B103 cells by Fura-2AM dye based Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 4(Mouse)
The University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  260nMAssay Description:Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 3(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  830nMAssay Description:Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  350nMAssay Description:Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  17nMAssay Description:Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 3(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  263nMAssay Description:Agonistic activity against lysophosphatidic acid receptor 3 using [35S]GTP-gamma-S as radioligand tested in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 2(Human)
The University of Utah

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataEC50:  6.80nMAssay Description:Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAutotaxin(Human)
Technical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataKi:  100nMAssay Description:Noncompetitive type inhibition of human autotaxin at free state isolated from MDA-MB-231 cells assessed as blockade of FS3 substrate hydrolysis by FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed