BDBM16469 2-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acid::CHEMBL363387::IDD-676::Indoleacetic Acid Inhibitor 9::Lidorestat::{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acid

SMILES c1ccc2c(c1)c(cn2CC(=O)O)Cc3nc4c(c(cc(c4s3)F)F)F

InChI Key InChIKey=KYHVTMFADJNSGS-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 16469   

TargetAldo-keto reductase family 1 member B1(Human)
The Institute For Diabetes Discovery

LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member A1(Human)
The Institute For Diabetes Discovery

LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 2.70E+4nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Slovak Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
The Institute For Diabetes Discovery

LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
The Institute For Diabetes Discovery

LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human recombinant aldose reductase 1 after 10 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)