BDBM50241179 (S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole (Levamisole)::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(Levamisole)::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(tetramisole)::CHEMBL1454::LEVAMISOLE::LEVAMISOLE HYDROCHLORIDE::TCMDC-125847::cid_68628::levamisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole::tetramisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole

SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1

InChI Key InChIKey=HLFSDGLLUJUHTE-UHFFFAOYSA-N

Data  4 KI  22 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50241179   

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TNAP by analogous luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human IAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human TNAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of human TNAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human IAP using CDP-star as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2019
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Universit£T Rostock

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2019
Entry Details Article
PubMed
TargetAlkaline phosphatase, placental type(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAlkaline phosphatase, placental type(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of intestinal alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of intestinal alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of IAP by analogous luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCorticotropin-releasing factor-binding protein(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataEC50: >5.30E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetPhospholipase A-2-activating protein(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PLAP by analogous luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Bovine)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMpH: 7.8Assay Description:Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, placental type(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMpH: 7.8Assay Description:Inhibition of human placental alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, placental type(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMpH: 10.4Assay Description:Inhibition of human placental alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Bovine)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 4.00E+5nMpH: 10.4Assay Description:Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Universit£T Rostock

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Universit£T Rostock

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 2.02E+4nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Universit£T Rostock

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 1.92E+4nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Universit£T Rostock

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataIC50: 1.92E+4nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Universit£T Rostock

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataKi:  1.81E+3nMAssay Description:Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataKi:  1.60E+4nMpH: 9.8Assay Description:Inhibition of human tissue non-specific alkaline phosphatase at pH 9.8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of TNSALPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179(6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole...)
Affinity DataKi:  9.30E+4nMAssay Description:Inhibition of recombinant TNAPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed