BDBM50312006 CHEMBL1076438::Lecanindole D

SMILES C[C@@]12[C@H](Cc3c1[nH]c1ccccc31)CC[C@@]1(O)C(C)(C)[C@H](O)CC[C@]21C

InChI Key InChIKey=QJRNEHJGTLWRJJ-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50312006   

TargetAndrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at androgen receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataIC50: 3.00E+6nMAssay Description:Antagonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at estrogen receptor alpha ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by lucife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at estrogen receptor alpha ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at estrogen receptor beta ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataEC50:  1.10nMAssay Description:Activation of progesterone receptor in human T47D cells after 20 hrs by PRE-tagged luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataIC50: 57.3nMAssay Description:Displacement of [3H]progesterone from progesterone receptor in human T47D cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312006(Lecanindole D | CHEMBL1076438)
Affinity DataIC50: 5.5nMAssay Description:Displacement of progesterone from progesterone receptor in human T47D cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed