BDBM50022889 (2,8-Bis-trifluoromethyl-quinolin-4-yl)-(1-methyl-piperidin-2-yl)-methanol::(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol::(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol( Mefloquine)::(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol; (Mefloquine or MF)::(2,8-bis(trifluoromethyl)quinolin-4-yl)(piperidin-2-yl)methanol::(S)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-(R)-piperidin-2-yl-methanol::(S)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol::(S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol::2,8-di(trifluoromethyl)-4-quinolyl-hexahydro-2-pyridinylmethanol(Mefloquine)::2-[(2,8-Bis-trifluoromethyl-quinolin-4-yl)-hydroxy-methyl]-piperidinium::CHEMBL416956::GNF-Pf-5544::Lariam::MEFLOQUINE::[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol::med.21724, Compound Mefloquine::melfoquine::rac-mefloquine::rel-(2,8-bis(trifluoromethyl)quinolin-4-yl)(piperidin-2-yl)methanol

SMILES OC(C1CCCCN1)c1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=XEEQGYMUWCZPDN-UHFFFAOYSA-N

Data  8 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50022889   

TargetGlycine receptor subunit alpha-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataEC50:  2.50E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 4.33E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 5.62E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 5.62E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 5.62E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataEC50:  7.41E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Walter Reed Army Institute of Research

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of Plasmodium falciparum cyclin-dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataEC50:  1.56E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetHistidine-rich protein PFHRP-II(malaria parasite P. falciparum)
Kyoto Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataIC50: 3.15E+5nMAssay Description:Inhibition of Tween 20-induced beta-hematin formation by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed