BDBM50001747 (+)-Kadsurenone::(Kadsurenone)5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-methyl-3,3a-dihydro-2H-benzofuran-6-one::5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-methyl-3,3a-dihydro-2H-benzofuran-6-one::CHEMBL296958::KADSURENONE

SMILES COc1ccc(cc1OC)[C@H]1OC2=CC(=O)C(CC=C)=C[C@]2(OC)[C@@H]1C

InChI Key InChIKey=VDYACOATPFOZIO-UHFFFAOYSA-N

Data  2 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50001747   

TargetPlatelet-activating factor receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2012
Entry Details Article

TargetPlatelet-activating factor receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 200nMAssay Description:Inhibition concentration required to block 50% of the specific [3H]PAF binding, obtained from Chiralpak column at low temperatures.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 120nMAssay Description:Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 240nMAssay Description:Inhibitor concentration required to block 50 %of the specific [3H]PAF binding to rabbit platelet membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 100nMAssay Description:Inhibitor concentration required to block 50% of the specific [3H]PAF binding, obtained as natural product.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 2.56E+4nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataIC50: 2.46E+5nMAssay Description:Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Human)
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataKi:  225nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details
PubMed
TargetPlatelet-activating factor receptor(Human)
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50001747(5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-meth...)
Affinity DataKi:  231nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details
PubMed