BDBM50091818 CHEMBL61743::Isoquinolin-3-ylamine::uPa_46

SMILES c1ccc2cnc(cc2c1)N

InChI Key InChIKey=VYCKDIRCVDCQAE-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50091818   

TargetNitric oxide synthase, inducible(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091818(CHEMBL61743 | uPa_46 | Isoquinolin-3-ylamine)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50091818(CHEMBL61743 | uPa_46 | Isoquinolin-3-ylamine)
Affinity DataIC50: 3.76E+5nMAssay Description:Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50091818(CHEMBL61743 | uPa_46 | Isoquinolin-3-ylamine)
Affinity DataKi: >3.00E+4nM ΔG°: >-6.17kcal/molepH: 7.4 T: 2°CAssay Description:Abbott uPA__Urokinase Human - Ki(uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details PubMed
LigandPNGBDBM50091818(CHEMBL61743 | uPa_46 | Isoquinolin-3-ylamine)
Affinity DataKi: >3.00E+4nMAssay Description:Photometric_Method1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R