BDBM50252513 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one::9-OH-risperidone::9-hydroxy risperidone::CHEMBL1621::Invega::PALIPERIDONE

SMILES Cc1nc2C(O)CCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12

InChI Key InChIKey=PMXMIIMHBWHSKN-UHFFFAOYSA-N

Data  69 KI  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 99 hits for monomerid = 50252513   

TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to 5HT2A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  1.21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Mouse)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to D2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to alpha2C adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  3.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  4nMAssay Description:Binding affinity to alpha2B adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetAlpha-1A adrenergic receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  4.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  4.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  4.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 5.20nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  6.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  6.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  7.30nMAssay Description:Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  7.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)TBA
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to D3 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 8.30nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  9.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  10.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha2A adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetAlpha-1A adrenergic receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha1A adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  19nMAssay Description:Binding affinity to 5HT2C receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
Target5-hydroxytryptamine receptor 1B(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(1B) dopamine receptor(Human)TBA
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  29nMAssay Description:Binding affinity to D5 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(4) dopamine receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  34nMAssay Description:Binding affinity to H1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(4) dopamine receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  38nMAssay Description:Binding affinity to D4 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
Target5-hydroxytryptamine receptor 2C(Pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
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