BDBM50029150 3-(2-Piperidin-4-yl-ethyl)-1H-indole::CHEMBL276520::Indalpine

SMILES C(Cc1c[nH]c2ccccc12)C1CCNCC1

InChI Key InChIKey=SADQVAVFGNTEOD-UHFFFAOYSA-N

Data  16 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50029150   

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50: 30nMAssay Description:In vivo inhibition of uptake of 5-HT in human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50: 10nMAssay Description:Inhibition of uptake of 5-HT in rat brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of uptake of dopamine (DA) rat brain striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of uptake of noradrenaline in rat brain hypothalamusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  1.72nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  2nMAssay Description:Effect of compound on Serotonin transporter uptake from rat cortex using [3H]citalopram as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  2nMAssay Description:In vitro inhibitory constant against [3H]paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  2.5nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]paroxetine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
In Depth
Date in BDB:
3/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  50.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  513nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  794nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  1.04E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  2.76E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  3.24E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetBeta-arrestin-2(Bovine)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  3.24E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
Target5-hydroxytryptamine 1D receptor(Bovine)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  3.63E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  4.47E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50029150(CHEMBL276520 | 3-(2-Piperidin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  9.12E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed