BDBM50013786 1-Methyl-9H-beta-carboline::1-Methyl-9H-beta-carboline (Harman)::1-Methyl-beta-carboline::1-methyl-9H-pyrido[3,4-b]indole::CHEMBL12014::HARMAN::Harmane::cid_5281404

SMILES Cc1c2c(ccn1)c3ccccc3[nH]2

InChI Key InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N

Data  1 KI  7 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50013786   

TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetAcetylcholinesterase(Electric eel)
Naresuan University

Curated by ChEMBL
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of electric eel AChE using acetylcholine iodide as substrate measured every 5 sec for 2 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetChitinase(Onchocerca volvulus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataIC50: 7.33E+3nMAssay Description:Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as releas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 75 mins by UV ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCholinesterase(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BuChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataIC50: 29nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50013786(cid_5281404 | Harmane | 1-Methyl-beta-carboline | ...)
Affinity DataKi:  8.60E+4nMAssay Description:Inhibitory effect on Bufuralol 1'-hydroxylation by human liver microsomes (Ki = apparent inhibition constant)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed