BDBM50207159 2-aminoguanidine::2-azanylguanidine::AMINOGUANIDINE::CHEMBL225304::Guanyl hydrazine::Imino semicarbazide::Monoaminoguanidine::hydrazinecarboximidamide

SMILES C(=N)(N)NN

InChI Key InChIKey=HAMNKKUPIHEESI-UHFFFAOYSA-N

Data  2 KI  18 IC50  1 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50207159   

TargetNitric oxide synthase, inducible(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCatalase(Bovine)
University of California

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of Bos taurus (bovine) CAT in liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetAlbumin(Bovine)
Unidad De Gen�Mica Avanzada (Langebio)

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataEC50:  2.60E+7nMAssay Description:Antiglycation activity in bovine serum albumin assessed as inhibition of advanced glycated end product formation in presence of D-glucose by spectrof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 4.50E+3nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Rat)
Korean Institute of Oriental Medicine (Kiom)

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Sprague-Dawley rat lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 2.85E+4nMAssay Description:Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Mouse)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 2.66E+4nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 5.40E+4nMAssay Description:Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Mouse)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 9.00E+3nMAssay Description:Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.10E+9nMAssay Description:Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 7.20E+4nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibitory activity against neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Rat)
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of iNOS-mediated NO production in IL-1beta/IFNgamma-stimulated rat RINmF cells by Griess reactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataKi:  140nMAssay Description:Tested for ability to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNitric oxide synthase, brain(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed